sickle cell anemia treatment guidelines

The American Society of Hematology (ASH) released evidence-based 2020 guidelines on the management of acute and chronic pain in pediatric and adult patients with sickle cell disease (SCD). The lack of understanding of the biological complexities associated with acute and chronic pain, combined with the lack of evidence on which to base recommendations, has made the management of pain for children and adults with SCD a significant clinical challenge. Ranging from pharmacological to nonpharmacological interventions and analgesic delivery, the panel decided on 18 recommendations for the management of acute and chronic pain; however, due to low certainty evidence, most recommendations made are conditional following close balance of benefits and harms. Associate Professor Division of Hematology-Oncology  For PatientsFor CliniciansStrong recommendationsMost patients would want the recommended course of action; only some would not.The majority of patients would want the recommended course of action, but many would not. George Buchanan, M.D. Director, Texas Children's Center for Global Health This material may not be published, broadcast, rewritten or redistributed in any form without prior authorization. Receive automatic alerts about NHLBI related news and highlights from across the Institute. Health Supervision for Children with Sickle Cell Disease. Formal decision aids may be beneficial for clinicians to help individual patients make decisions. This statement provides pediatricians in primary care and subspecialty practice with an overview of the genetics, diagnosis, clinical manifestations, and treatment of SCD. - Evidence-Based Guidance Decision aids may be helpful to aid patients to make decisions that align with their values and preferences. Director, Baylor International Hematology Center of Excellence University of Florida, William Savage, MD The guidelines aim to support patients, clinicians, caregivers, hematologists, and other healthcare workers with decisions associated with pain management in SCD. University of Texas Southwestern Medical Center at Dallas, Barbara Yawn, M.D., M.S.P.H. University of North Carolina at Chapel Hill, Samir Ballas, M.D. here. We hope you’re enjoying the latest clinical news, full-length features, case studies, and more. Formal decision aids are most likely not required to help patients make decisions that align with their values and preferences.Clinicians must recognize that individual patients may require different choices that reflect their values and preferences, and that not all options are appropriate for all patients. Consequently, few studies have been conducted on the use and role of nonopioid pharmacological and nonpharmacological treatments for acute and chronic SCD pain. Your use of this website constitutes acceptance of Haymarket Media’s Privacy Policy and Terms & Conditions. Interpretation Definitions of Strong and Conditional Recommendations Table. Director, Sickle Cell Center for Adults at Johns Hopkins, Richard Lottenberg, M.D. Director of Sickle Cell Services  Professor of Pediatrics and Director Associate Professor of Obstetrics & Gynecology  Formal decision aids are most likely not required to help patients make decisions that align with their values and preferences. Copyright © 2020 Haymarket Media, Inc. All Rights Reserved Johns Hopkins University, Paula Tanabe, Ph.D., R.N., M.S.N., M.P.H. Enjoying our content? Please login or register first to view this content. Adjunct Professor, Family and Community Health Infection. These guidelines were developed by an expert panel composed of health care professionals with expertise in family medicine, general internal medicine, adult and pediatric hematology, psychiatry, transfusion medicine, obstetrics and gynecology, emergency department nursing, and evidence-based medicine. Ultimately, these gaps in knowledge and treatment have led to barriers in effective and targeted interventions. The majority of patients would want the recommended course of action, but many would not. Director of Research Professor of Medicine For the full list of recommendations, refer to the complete guidelines, published in Blood Advances. Sign in Duke University Medical Center, Lanetta Jordan, M.D., M.P.H., M.S.P.H. Dosing should be based on baseline opioid therapy and previous effective therapy (conditional recommendation based on moderate certainty in evidence about effects for adults; conditional recommendation based on low certainty in the evidence about effects for children). Department of Pediatrics The purpose of these guidelines is to help people living with sickle cell disease (SCD) receive appropriate care by providing the best science-based recommendations to guide practice decisions. - Drug Monographs Taking the following steps to stay healthy may help you avoid complications of sickle cell anemia: 1. NHLBI sponsored the development of these guidelines to assist health care professionals in the management of common issues, including routine health maintenance, the recognition and treatment of common acute and chronic complications and comorbidities of SCD, as well as the indications for and monitoring of hydroxyurea and blood transfusion therapy. Use of Standardized Protocols to Treat Acute SCD Pain in the Acute Care Setting. - Full-Length Features Your doctor might recommend a folic acid supplement. The target audience is primary care providers and other clinicians, nurses, and staff who provide emergency or continuity care to individuals with SCD.

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